Company Filing History:
Years Active: 1997-2011
Title: Innovations of Stephen V O'Gorman
Introduction
Stephen V O'Gorman is a prominent inventor based in San Diego, CA. He has made significant contributions to the field of genetic engineering, particularly in the manipulation of chromosomal sequences. With a total of 8 patents, his work has advanced the understanding and application of site-specific recombination in both mammalian and plant cells.
Latest Patents
One of his latest patents focuses on "Site-specific recombination in eukaryotes and constructs useful therefor." This invention provides a means of efficiently manipulating chromosomal sequences in mammalian cells and in mice. The patent describes embryonic stem cells containing recombinase nucleic acid constructs that are expressed in the male germline. This innovation simplifies current protocols for producing mice with homologously recombined alleles that have been rearranged by a site-specific recombinase. The data from his research indicate that ProCre nucleic acid constructs facilitate the production of subtle, conditional, or tissue-specific mutations in mice, as well as the analysis of mice with recombinase-conditional lethal alleles.
Another aspect of his recent work involves the generation of recombinant plants through the manipulation of chromosomal sequences in plant cells. This patent also relates to nucleic acid constructs that utilize a germline-specific promoter associated with a recombinase coding sequence. Methods for introducing these constructs into various plant species are also provided.
Career Highlights
Stephen V O'Gorman has established himself as a key figure in genetic research. His work at the Salk Institute for Biological Studies has allowed him to collaborate with leading scientists in the field. His innovative approaches have led to advancements that are crucial for both basic research and practical applications in biotechnology.
Collaborations
Stephen has worked closely with Geoffrey M Wahl, a fellow researcher at the Salk Institute. Their collaboration has contributed to the development of groundbreaking techniques in genetic manipulation.
Conclusion
Stephen V O'Gorman's contributions to the field of genetic engineering are noteworthy. His patents and research have paved the way for new methodologies in both mammalian and plant genetics. His work continues to influence the scientific community and drive innovation in biotechnology.