Location History:
- Arlington, MA (US) (1997 - 2000)
- New York, NY (US) (1997 - 2000)
- Germantown, MD (US) (1998 - 2000)
Company Filing History:
15 out of 712 
1 out of 832,912 Years Active: 1997-2000
Title: **Stephen D. Wolpe: Innovator in Inflammatory Cytokine Research**
Introduction
Stephen D. Wolpe, an accomplished inventor based in Arlington, MA, has made significant contributions to the field of inflammatory cytokines, holding an impressive number of 16 patents. His inventive work focuses on the mechanisms of inflammation and potential therapeutic applications, highlighting the importance of cytokines in medical science.
Latest Patents
Among his latest patents, Wolpe has developed compositions comprising antibodies that target macrophage-derived inflammatory cytokines. One notable patent describes an inflammatory cytokine isolated from cells incubated with a stimulator material. This cytokine is capable of binding to heparin, inducing localized inflammation evidenced by polymorphonuclear cell infiltration when administered subcutaneously. It exhibits potent in vitro chemotactic activity while maintaining low chemokinetic activity in polymorphonuclear cells. Importantly, it does not suppress the activity of the anabolic enzyme lipoprotein lipase, nor does it cause cytotoxicity in cachectin/TNF-sensitive cells. The cDNA of the cytokine has been sequenced, revealing a length of 74 amino acids and a molecular weight of 7,908, proposing various diagnostic and therapeutic utilities.
Another patent focuses on the macrophage-derived inflammatory mediators, MIP-1.alpha. and MIP-1.beta., which were also isolated under similar experimental conditions. These peptides, resolved into a doublet of approximately 8,000 daltons, show distinct cDNAs that have been cloned and sequenced, offering further insights into their potential applications in diagnosis and therapy.
Career Highlights
Throughout his career, Stephen D. Wolpe has been associated with prestigious research institutions, including The Rockefeller University. His work at these institutions has paved the way for groundbreaking discoveries in the field of inflammation, particularly pertaining to cytokine biology.
Collaborations
Wolpe has collaborated with notable scientists such as Anthony Cerami and Bruce A. Beutler. These collaborations have facilitated the sharing of knowledge and expertise, thus enhancing the quality of research and innovation in cytokine studies.
Conclusion
Stephen D. Wolpe exemplifies the spirit of innovation in medical research, particularly in understanding inflammatory processes through his patented inventions. His contributions continue to impact the fields of diagnostics and therapeutics, as he works towards unlocking the potential of inflammatory cytokines in medical science. His commitment to research is evident in his extensive patent portfolio and collaborative efforts with renowned peers.