Company Filing History:
Years Active: 1990-1992
Title: The Innovations of Stephen A. Duffy
Introduction
Stephen A. Duffy is a notable inventor based in Florissant, MO (US). He has made significant contributions to the field of biochemistry, particularly in the purification of immunoglobulins and tissue plasminogen activator (tPA). With a total of 2 patents, his work has implications for clinical applications and drug administration.
Latest Patents
Duffy's latest patents include "Efficient large-scale purification of immunoglobulins and derivatives." This invention presents improved methods for the direct purification of product immunoglobulins or their derivatives from large volumes of mammalian cell culture medium. The process involves directly subjecting the cell culture medium to cation exchange treatment, allowing for the adsorption of the product while excluding contaminants. The eluted product can then be recycled or subjected to anion exchange for further purification, making it suitable for clinical applications.
Another significant patent is the "Method to solubilize tissue plasminogen activator." This method allows for practical amounts of tPA, whether secreted by cells or prepared recombinantly, to be solubilized in an aqueous medium at pH 5-14. By using a solubilizing amount of a basic amino acid, preferably in the presence of a citric acid moiety, tPA can be solubilized at concentrations of up to 50 mg. This advancement is crucial as it enables smaller volumes for purification and allows for single injections of the drug instead of intravenous administration.
Career Highlights
Throughout his career, Stephen A. Duffy has worked with prominent companies such as Centocor, Inc. and Invitron Limited. His experience in these organizations has contributed to his expertise in biochemistry and patent development.
Collaborations
Duffy has collaborated with notable coworkers, including Christopher P. Prior and Billy J. Moellering. Their combined efforts have likely enhanced the innovation and development of his patented technologies.
Conclusion
Stephen A. Duffy's contributions to the field of biochemistry through his patents demonstrate his commitment to advancing medical science. His innovative methods for purifying immunoglobulins and solubilizing tPA have the potential to significantly impact clinical practices.