The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 1992
Filed:
Dec. 09, 1987
Applicant:
Inventors:
Christopher P Prior, Ballwin, MO (US);
Stephen A Duffy, Florissant, MO (US);
Billy J Moellering, St. Louis, MO (US);
Assignee:
Centocor, Incorporated, Malvern, PA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; C07K / ; B01D / ;
U.S. Cl.
CPC ...
5303881 ; 530413 ; 530416 ; 530417 ; 530418 ; 530808 ; 530830 ; 424 858 ; 210635 ; 210656 ;
Abstract
Improved methods for direct purification of product immunoglobulins or their derivatives from large volumes of mammalian cell culture medium include directly subjecting the cell culture medium to cation exchange treatment, so as to adsorb the product but not the contaminants. The eluted product is then recycled, or is applied to anion exchange, for further purification, and optionally subjected to additional steps. The product may be obtained in a form suitable for clinical applications, if desired.