Stefan Hettwer

Title: The Innovations of Stefan Hettwer

Introduction

Stefan Hettwer is a notable inventor based in Zurich, Switzerland. He has made significant contributions to the field of medical science, particularly in the area of neurobiology. With a total of 2 patents, his work focuses on developing innovative solutions for muscle strength restoration and neurotrypsin inhibition.

Latest Patents

Hettwer's latest patents include a "Modified agrin-fragment capable of restoring muscle strength for use as a medicament." This invention involves a modified agrin fragment that possesses in vivo activity, comprising at least the domains LG2 and LG3 of human agrin in a covalently interlinked form. The modification ensures that the fragment cannot be cleaved by neurotrypsin, making it a promising candidate for medicinal use. Another significant patent is the "Method for determining inhibitors of neurotrypsin." This method allows for the identification of compounds that inhibit neurotrypsin by incubating them with agrin and measuring the cleavage of agrin in an aqueous buffer solution. The findings from this method can lead to the development of treatments for diseases caused by synaptic deficiencies, such as skeletal muscle atrophy and cognitive disturbances.

Career Highlights

Throughout his career, Hettwer has worked with prominent organizations, including Neurotune AG and the University of Zurich. His experience in these institutions has allowed him to collaborate with leading experts in the field and contribute to groundbreaking research.

Collaborations

Hettwer has collaborated with notable colleagues such as Stefan Kucsera and Jan Willem Vrijbloed. These partnerships have further enhanced his research and innovation capabilities.

Conclusion

Stefan Hettwer's contributions to the field of neurobiology through his patents and collaborations highlight his role as an influential inventor. His work continues to pave the way for advancements in medical treatments and therapies.