The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 2011
Filed:
Mar. 29, 2006
Peter Sonderegger, Zürich, CH;
Stefan Hettwer, Zürich, CH;
Marc F. Bolliger, Brittnau, CH;
Birgit Dreier, Adlikon, CH;
Beat Kunz, Winterthur, CH;
Daniel Lüscher, Holziken, CH;
Raymond Reif, Zürich, CH;
Susanne Sales, Zürich, CH;
Peter Sonderegger, Zürich, CH;
Stefan Hettwer, Zürich, CH;
Marc F. Bolliger, Brittnau, CH;
Birgit Dreier, Adlikon, CH;
Beat Kunz, Winterthur, CH;
Daniel Lüscher, Holziken, CH;
Raymond Reif, Zürich, CH;
Susanne Sales, Zürich, CH;
University of Zurich, Zurich, CH;
Abstract
The invention relates to a method for determining whether a compound is a neurotrypsin inhibitor, characterized in that the compound is incubated together with neurotrypsin, a variant thereof or a fragment comprising the protease domain and with a protein or peptide comprising agrin, a variant thereof or a fragment comprising the α- or the β-cleavage site of agrin, in an aqueous buffer solution, and the amount of cleavage of agrin is measured. Additionally, the invention relates to inhibitors of neurotrypsin found by this method, in particular to compounds of formula wherein Haland Halare fluorine, chlorine or bromine, and the use of such inhibitors for the treatment and/or prophylaxis of diseases caused by deficiency of synapses, for example skeletal muscle atrophy, schizophrenia, and cognitive disturbance.