Simon Geoffrey Lillico

Title: Simon Geoffrey Lillico: Innovator in Genetic Engineering

Introduction

Simon Geoffrey Lillico is a prominent inventor based in Midlothian, GB. He has made significant contributions to the field of genetic engineering, particularly in livestock and animal health. With a total of 3 patents, his work focuses on innovative methods to enhance animal breeding and disease resistance.

Latest Patents

One of his latest patents is titled "NANOS knock-out that ablates germline cells." This invention provides livestock animals and methods to create recipient animals for spermatogonial stem cell transplantation through modulation of the NANOS gene. In one embodiment, genome editing is used to create animals with insertions or deletions (indels) that inactivate or otherwise modulate NANOS gene activity. The resulting males lack functional germ cells yet retain functional somatic cells, while females remain fertile. These males can then be transplanted with donor spermatogonial stem cells and used for breeding.

Another significant patent involves genetically edited pigs comprising a modification in the RELA gene. This invention relates to a genetically edited animal, specifically a pig in which the expression or activity of the RELA protein has been modified. Such pigs exhibit at least partial protection against the African Swine Fever Virus. The invention also provides a cell nucleus, germ cell, stem cell, gamete, blastocyst, embryo, fetus, and/or donor cell of a non-human animal comprising a genetic modification that alters the expression or function of the RELA protein, along with methods for editing the genome of animals and screening the efficacy of pharmaceutical agents in such animals.

Career Highlights

Simon Geoffrey Lillico has worked with esteemed institutions such as the University of Edinburgh and Washington State University. His research has significantly advanced the understanding of genetic modifications in livestock, contributing to improved agricultural practices.

Collaborations

Some of his notable coworkers include Christopher Bruce Alexander Whitelaw and Tahar Ait-Ali. Their collaborative efforts have furthered the impact of Lillico's innovations in the field of genetic engineering.

Conclusion

Simon Geoffrey Lillico stands out as an influential inventor in genetic engineering, with a focus on enhancing livestock health and breeding practices. His innovative patents reflect a commitment to advancing agricultural biotechnology and improving animal welfare.