The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 01, 2024
Filed:
Mar. 20, 2020
Washington State University, Pullman, WA (US);
University of Maryland, College Park, MD (US);
The University Court of the University of Edinburgh, Edinburgh, GB;
Jon Michael Oatley, Pullman, WA (US);
Christopher Bruce Alexander Whitelaw, Biggar, GB;
Simon Geoffrey Lillico, Penicuik, GB;
Bhanu Prakash Telugu, Laurel, MD (US);
Washington State University, Pullman, OR (US);
University of Maryland, College Park, MD (US);
The University Court of The University of Edinburgh, Edinburgh, GB;
Abstract
The present invention provides livestock animals and methods to create recipient animals for spermatogonial stem cell transplantation through modulation of the NANOS gene. In one embodiment genome editing issued to create animals with insertions or deletions (indels) that inactivate or otherwise modulate NANOS gene activity so that resulting males lack functional germ cells yet retain functional somatic cells, and females are fertile. These males can then be transplanted with donor spermatogonial stem cells and used for breeding.