Sidney N Wolfe

Title: Sidney N Wolfe: Innovator in Interferon Research

Introduction

Sidney N Wolfe is a notable inventor based in Lafayette, CA (US), recognized for his contributions to the field of interferon research. He holds a total of 4 patents, showcasing his innovative approaches to the purification and stabilization of interferon-beta (IFN-β).

Latest Patents

Wolfe's latest patents include methods for the purification and recovery of interferon-beta. One of his significant contributions is a method that involves precipitating substantially purified IFN-β and then dissolving it in a guanidine hydrochloride (HCl) solution. This process allows for the renaturation of the protein through dilution with a suitable buffer. Additionally, he has developed stabilized pharmaceutical formulations that comprise IFN-β and highly purified mannitol, which helps reduce the formation of IFN-β adducts, enhancing the stability of the compositions.

Career Highlights

Throughout his career, Sidney N Wolfe has worked with prominent companies such as Novartis Vaccines & Diagnostics and Chiron Corporation. His work in these organizations has significantly advanced the understanding and application of interferon in therapeutic settings.

Collaborations

Wolfe has collaborated with notable individuals in his field, including Maninder S Hora and Bret A Shirley. These collaborations have contributed to the development of innovative solutions in interferon research.

Conclusion

Sidney N Wolfe's work in the purification and stabilization of interferon-beta has made a lasting impact on the pharmaceutical industry. His innovative patents and collaborations continue to influence the field of biotechnology.