Shobha Potluri

Title: Innovations by Inventor Shobha Potluri in Immunotherapy

Introduction: Shobha Potluri is an accomplished inventor located in South San Francisco, California. With a focus on groundbreaking innovations in immunotherapy, Potluri has made significant contributions to the field, particularly through the development of advanced chimeric antigen receptors.

Latest Patents: Potluri holds a patent for ROR1 targeting chimeric antigen receptor. This patent describes polynucleotides that encode a chimeric polypeptide consisting of a c-Jun polypeptide, a ROR1-binding protein, and a truncated EGF receptor. Additionally, it includes cells, such as T cells, that express CARs comprising a ROR1-binding protein while overexpressing a c-Jun polypeptide. The overexpression of c-Jun in CAR T cells is shown to enhance their functionality by reducing or preventing exhaustion, thereby improving therapeutic outcomes.

Career Highlights: Shobha Potluri is currently employed at Lyell Immunopharma, Inc., a company renowned for its innovative approach to harnessing the immune system to combat cancer. Her work exemplifies the integration of cutting-edge research with practical applications in patient care.

Collaborations: Among her notable colleagues are Spencer Park and Queenie Vong, highlighting a collaborative environment that fosters innovation and the sharing of ideas. Their teamwork is essential in driving forward the advancements in their shared field of expertise.

Conclusion: Shobha Potluri's contributions through her patent and her role at Lyell Immunopharma illustrate the vital connection between innovative research and the development of effective therapies. As the field of immunotherapy continues to evolve, Potluri's work serves as an important foundation for future discoveries and advancements.