The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 2024
Filed:
Feb. 24, 2022
Lyell Immunopharma, Inc., South San Francisco, CA (US);
Spencer Park, Seattle, WA (US);
Queenie Vong, South San Francisco, CA (US);
Blythe Sather, South San Francisco, CA (US);
Byoung Ryu, South San Francisco, CA (US);
Marc Lajoie, South San Francisco, CA (US);
Howell Moffett, South San Francisco, CA (US);
Brian Weitzner, South San Francisco, CA (US);
Yun Song, South San Francisco, CA (US);
Scott Boyken, South San Francisco, CA (US);
Neeraj Sharma, South San Francisco, CA (US);
Shobha Potluri, South San Francisco, CA (US);
Bijan Boldajipour, South San Francisco, CA (US);
Lyell Immunopharma, Inc., South San Francisco, CA (US);
Abstract
The present disclosure relates to polynucleotides encoding a chimeric polypeptide comprising a c-Jun polypeptide, a ROR1-binding protein, and a truncated EGF receptor. Also provided are cells (e.g., T cells) expressing CARs comprising a ROR1-binding protein and overexpressing a c-Jun polypeptide. Overexpression of c-Jun in CAR T cells confers improved properties, e.g., reducing or preventing exhaustion.