This inventor holds 3 USPTO granted patents. Top assignees: Chemo-Sero-Therapeutic Research Institute, Teijin Limited, The Chemo-Sero-Therapeutic Res. Inst.. Active years: 1986-1987.
Company Filing History:
2 out of 151 
1 out of 1,605 
1 out of 1 Years Active: 1986-1987
Title: Innovations of Shin Sakuma
Introduction
Shin Sakuma is a notable inventor based in Kumamoto, Japan. He has made significant contributions to the field of biotechnology, particularly in the development of methods related to Bordetella pertussis. With a total of 3 patents, his work has implications for medical treatments and vaccine production.
Latest Patents
One of his latest patents is a method for the purification of LPF-HA. This method allows for the production of highly pure LPF-HA (Leucocytosis-promoting Factor agglutinin) from culture media of Bordetella pertussis using affinity chromatography with denatured ceruloplasmin as a ligand. The LPF-HA produced through this method is highly pure and contains minimal endotoxin from B. pertussis, making it useful for various reagents, diabetes treatment, and pertussis vaccines. Another significant patent is the method for the production of HA fraction containing protective antigens. This method enables the industrial-scale production of HA fraction containing protective antigens of Bordetella pertussis, which includes F-HA and LPF-HA. The process involves culturing B. pertussis in a liquid medium with cyclodextrin or its derivatives, controlling various growth conditions, and harvesting the HA fraction at specific growth phases.
Career Highlights
Shin Sakuma has worked with reputable organizations such as the Chemo-Sero-Therapeutic Research Institute. His contributions to the field have been recognized and have paved the way for advancements in vaccine development and therapeutic applications.
Collaborations
He has collaborated with notable colleagues, including Hisashi Kitagawa and Akihiro Ginnaga, which has further enriched his research and innovations.
Conclusion
Shin Sakuma's work exemplifies the impact of innovative methods in biotechnology, particularly in the context of public health. His patents contribute significantly to the fields of medicine and vaccine production, showcasing the importance of research and development in addressing health challenges.