Location History:
- Toronto, CA (1998 - 2001)
- Mississauga, CA (2002 - 2009)
Company Filing History:
Years Active: 1998-2009
Title: Shigui Liu: Innovator in Cardiac Biomarkers
Introduction
Shigui Liu is a prominent inventor based in Mississauga, Canada. He has made significant contributions to the field of cardiac biomarkers, particularly through his innovative work on troponin I polypeptide fragments. With a total of 5 patents to his name, Liu's inventions have the potential to enhance the detection and treatment of myocardial infarction.
Latest Patents
Liu's latest patents include groundbreaking inventions such as "Troponin I polypeptide fragments and uses thereof." This patent describes polypeptides that correspond to stable, circulating degradation products of troponin I (TnI). The fragments consist of a sequence from the N-terminus of native cardiac TnI, ranging from 95 to 115 amino acids, and may also include fragments that lack approximately 20 to 30 N-terminal amino acids. These fragments and their corresponding antibodies are useful for the sensitive detection of myocardial infarction and for purifying antibodies that are sensitive to troponin I degradation products.
Another notable patent is "Single-chain polypeptides comprising troponin I N-terminal fragments and troponin C." This invention relates to single-chain polypeptides and their genetic sequences that include a human cardiac troponin I N-terminal fragment and troponin C. The N-terminal fragment may or may not retain the intact N-terminus. These single-chain polypeptides can be expressed recombinantly and may include a linker or spacer polypeptide or peptide between the troponin sequences. They serve as controls or calibrators for troponin assays, aid in the purification of troponin subunits, and act as antigens for antibody preparation.
Career Highlights
Shigui Liu is currently associated with Spectral Diagnostics, Inc., where he continues to advance his research in cardiac biomarkers. His work has been instrumental in developing innovative solutions that address critical health issues related to heart diseases.
Collaborations
Liu collaborates with esteemed colleagues such as Qinwei Shi and Mingfu Ling, contributing to a dynamic research environment that fosters innovation and discovery.
Conclusion
Shigui Liu's contributions to the field of cardiac biomarkers through his patents and collaborations highlight his role as a leading inventor in medical research. His work has the potential to significantly impact