Shida Shen

Title: The Innovative Contributions of Shida Shen in Atmospheric Pressure Ion Source Technology

Introduction

Shida Shen is a remarkable inventor based in Branford, Connecticut, who has made significant strides in the field of atmospheric pressure ion source technology. Holding a total of five patents, her contributions have been pivotal in enhancing analytical processes, particularly in mass spectrometry.

Latest Patents

One of Shida Shen's latest patents focuses on the enhancement of atmospheric pressure ion source performance. This innovative work addresses the challenges faced when upstream sample preparation or separation processes are incompatible with downstream electrospray (ES) processes, leading to reduced mass spectroscopy (MS) signals. Shen has discovered new electrolytes that dramatically increase both positive and negative polarity analyte ion signals in electrospray mass spectrometry (ESMS) analysis. When compared to more conventional electrolytes, her novel electrolytes have shown improved performance. These new electrolyte species enhance the ES MS signal when added directly to the sample solution or incorporated into a second solution flow in an electrospray membrane probe. Additionally, running the ES membrane probe with specific electrolytes in its second solution has been found to further enhance ESMS signals compared to the standard use of these electrolytes directly in the sample solution. Furthermore, these electrolytes can be utilized in a reagent ion source configured in a combination atmospheric pressure ion source to significantly improve ionization efficiency.

Career Highlights

Throughout her career, Shida Shen has worked at renowned companies such as Analytica of Branford, Inc. and PerkinElmer Health Sciences, Inc., where she has honed her skills and knowledge in the field of analytical chemistry and mass spectrometry. Her experiences in these organizations have provided her with a robust foundation to pursue innovative solutions that address complex scientific challenges.

Collaborations

In her journey as an inventor, Shen has collaborated with esteemed colleagues, including Craig M. Whitehouse and Bruce A. Andrien, Jr. These collaborations have undoubtedly contributed to the depth and breadth of her innovative work, fostering an environment of knowledge sharing and ingenuity.

Conclusion

In summary, Shida Shen's innovative contributions, particularly regarding the enhancement of atmospheric pressure ion source technology, highlight her invaluable role in advancing the field of mass spectrometry. Her research not only enhances analytical capabilities but also opens new avenues for scientific inquiry, making her a notable figure among inventors in her domain.