The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 2013
Filed:
Apr. 01, 2011
Craig M. Whitehouse, Branford, CT (US);
Thomas White, Clinton, CT (US);
Shida Shen, Branford, CT (US);
Craig M. Whitehouse, Branford, CT (US);
Thomas White, Clinton, CT (US);
Shida Shen, Branford, CT (US);
PerkinElmer Health Sciences, Inc., Waltham, MA (US);
Abstract
Species that may be required to enhance an upstream sample preparation or separation process may be less compatible with the downstream electrospray (ES) processes and cause reduction in mass spectroscopy (MS) signal. New electrolytes have been found that increase positive and negative polarity analyte ion signal measured in ESMS analysis when compared with analyte ESMS signal achieved using more conventional electrolytes. The new electrolyte species increase ES MS signal when added directly to a sample solution or when added to a second solution flow in an electrospray membrane probe, it has also been found that running the ES membrane probe with specific electrolytes in the second solution of the ES membrane probe have been found to enhance ESMS signal compared to using the same electrolytes directly in the sample solution being electrosprayed. The new electrolytes can be added to a reagent ion source configured in a combination atmospheric pressure ion source to improve ionization efficiency.