Location History:
- Ipswich, MA (US) (2013 - 2021)
- Stoneham, MA (US) (2014 - 2024)
Company Filing History:
32 out of 336 
2 out of 832,843 Years Active: 2013-2024
Title: **Shengxi Guan: Innovator in High Fidelity Restriction Endonucleases**
Introduction
Shengxi Guan is an accomplished inventor based in Stoneham, MA, with an impressive portfolio of 34 patents. His work primarily focuses on developing advanced restriction endonucleases, which are crucial tools in molecular biology and genetics.
Latest Patents
Among his latest contributions to the field are two notable patents related to high fidelity restriction endonucleases. The first patent addresses methods and compositions for engineering mutant enzymes that exhibit reduced star activity, ensuring that the mutant enzymes have a fidelity index (FI) greater than that of their non-mutated counterparts in the same buffer. The second patent discusses systematic approaches to mutagenesis, combined with screening assays that allow for the selection of desired proteins. This method particularly aims to enhance specific properties of restriction endonucleases, such as reducing star activity, and includes compositions featuring these improved enzymes based on overall fidelity index enhancement.
Career Highlights
Shengxi Guan has made significant strides in his career, working with notable organizations such as New England Biolabs, Inc. His contributions have paved the way for innovations in the field of genetics, particularly relating to enzyme functionalities and engineering.
Collaborations
Throughout his professional journey, Guan has collaborated with esteemed colleagues, including Zhenyu Zhu and Aine Quimby. Together, they have contributed to advancements in the development of restriction endonucleases and have played vital roles in various projects within the biotechnology industry.
Conclusion
With a robust patent portfolio and a commitment to innovation in the field of molecular biology, Shengxi Guan continues to be a leading figure in the development of high fidelity restriction endonucleases. His research has significant implications for genetic engineering, making essential tools more efficient and reliable for scientists worldwide.