Company Filing History:
Years Active: 1999-2000
Title: Innovations by Sheila Garven
Introduction
Sheila Garven is a notable inventor based in Oakville, CA. She has made significant contributions to the field of protein expression and degradation. With a total of 2 patents, her work has advanced the understanding of how proteins can be effectively expressed in bacterial host cells.
Latest Patents
Garven's latest patents include a method for the expression of proteins in bacterial host cells. This method utilizes an aminopeptidase inhibitor to prevent the degradation of heterologous proteins by aminopeptidases. The inhibitors are designed based on the mechanism and substrate specificity of the target protease and the expressed protein. Another patent focuses on the proteases endogenous to Streptomyces cells, which degrade heterologous proteins secreted from these host cells. This patent identifies previously unknown proteases and discusses methods to alleviate degradation through selective inhibition or by using hosts with impaired protease production.
Career Highlights
Sheila Garven is currently employed at Cangene Corporation, where she continues her research and development in protein expression technologies. Her innovative approaches have positioned her as a key figure in her field.
Collaborations
Some of her notable coworkers include Daniel Bartfeld and Michael J Butler, who contribute to her research endeavors.
Conclusion
Sheila Garven's work in protein expression and degradation showcases her innovative spirit and dedication to advancing scientific knowledge. Her contributions are invaluable to the field and continue to inspire future research.