Sharron H Francis

Title: Sharron H Francis: Innovator in Phosphodiesterase Research

Introduction

Sharron H Francis is a notable inventor based in Nashville, TN (US). She has made significant contributions to the field of biochemistry, particularly in the study of phosphodiesterases. With a total of 5 patents to her name, her work has advanced the understanding of enzyme functions and their applications.

Latest Patents

Among her latest patents is the invention titled "Assay for phosphodiesterase function." This invention provides filter-based assays for measuring the binding of compounds to phosphodiesterases (PDEs). The assay allows for stoichiometric binding of compounds to PDEs, offering a highly sensitive measure of PDE binding and inhibition. Another significant patent is "Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materials." This invention includes novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. It also outlines methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds that modulate the enzymatic activity of cGB-PDE polypeptides.

Career Highlights

Sharron has worked at prestigious institutions such as the University of Washington and Vanderbilt University. Her research has been pivotal in enhancing the scientific community's understanding of phosphodiesterases and their role in various biological processes.

Collaborations

Throughout her career, Sharron has collaborated with esteemed colleagues, including Jackie D Corbin and Joseph A Beavo. These collaborations have further enriched her research and contributed to her innovative work in the field.

Conclusion

Sharron H Francis is a distinguished inventor whose work in phosphodiesterase research has led to significant advancements in biochemistry. Her patents reflect her dedication to innovation and her impact on the scientific community.