This inventor holds 8 USPTO granted patents and 2 published patent applications and 1 EPO patent. Top assignees: University of Southern California, Epiclone Inc., Mello Biotechnology, Inc.. Active years: 1999-2017.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
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Title: Innovations of Shao-Yao Ying in Stem Cell Research
Introduction
Shao-Yao Ying is a prominent inventor based in San Marino, California, known for his significant contributions to the field of stem cell research. With a total of 8 patents to his name, Ying has developed groundbreaking methods that advance our understanding of human embryonic stem-like cells and their potential applications in medicine.
Latest Patents
One of Ying's latest patents focuses on the generation of human embryonic stem-like cells using intronic RNA. This invention outlines a method for developing and selecting pluripotent cells through the transgenic expression of intronic microRNA-like RNA agents. The method allows for the creation of a non-naturally occurring intron that can be processed into mir-302-like RNA molecules in mammalian cells. This process induces specific gene silencing effects on differentiation-related genes, effectively reprogramming the cells into a pluripotent embryonic stem cell-like state. The resulting ES-like cells express key markers such as Oct3/4, SSEA-3, and SSEA-4, and can be directed into various tissue types for potential use in transplantation and gene therapies.
Another significant patent addresses the prevention of hyaluronan-mediated tumorigenetic mechanisms using intronic RNAs. Ying's research indicates that patterns of microRNA expression correlate with tumor cell differentiation in human prostate cancer. His findings reveal that specific miRNAs can bind to oncogenes or tumor suppressor genes, leading to targeted gene silencing and alterations in cellular tumorigenicity. Through in-vitro assays, Ying demonstrated that the miRNA mir-146a can suppress the expression of the ROCK1 gene, resulting in reduced cancer cell proliferation and metastasis.
Career Highlights
Ying has worked at the University of Southern California, where he has contributed to various research initiatives in stem cell biology and cancer treatment. His innovative approaches have garnered attention in the scientific community, leading to advancements in gene manipulation techniques.
Collaborations
Ying has collaborated with notable researchers such as Shi-Lung Lin and Cheng-Ming Chuong, further enhancing the impact of his work in the field.
Conclusion
Shao-Yao Ying's contributions to stem cell research and cancer treatment through his innovative patents highlight his role as a leading inventor in the scientific community. His work not only advances our understanding of pluripotent cells
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile