Sham Y Chan

Title: The Innovative Contributions of Sham Y Chan

Introduction

Sham Y Chan is a notable inventor based in El Sobrante, CA (US). He has made significant contributions to the field of protein expression, holding a total of 3 patents. His work focuses on developing methods and constructs that enhance the efficiency of protein production in mammalian cell cultures.

Latest Patents

One of Sham Y Chan's latest patents is titled "Methods and constructs for protein expression." This invention teaches methods, constructs, and host cells for the effective expression of a desired protein in mammalian cell culture, particularly emphasizing the efficient expression of human GGF2. Another important patent is "Method of selecting mammalian cell lines having improved productivity." This method involves selecting transfected cell lines for heterologous protein expression from a population of cells, some of which include an endogenous sequence for an amplifiable marker. The method is based on a minimum amplifiability index, which focuses on cell lines with relatively low productivity prior to amplification. This innovative approach allows for the selection of transfected cell lines that produce greater amounts of heterologous protein compared to those selected according to prior art.

Career Highlights

Sham Y Chan is currently employed at Bayer Corporation, where he continues to advance his research in protein expression technologies. His work has been instrumental in improving the productivity of mammalian cell lines, which is crucial for biopharmaceutical production.

Collaborations

Sham Y Chan collaborates with talented individuals in his field, including Van-Mai Tran and Shu-Lan Cheng. Their combined expertise contributes to the innovative research and development efforts at Bayer Corporation.

Conclusion

Sham Y Chan's contributions to the field of protein expression through his patents and work at Bayer Corporation highlight his role as a significant inventor. His innovative methods are paving the way for advancements in biopharmaceutical production.