The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 18, 1997
Filed:
Nov. 03, 1994
Sham Y Chan, El Sobrante, CA (US);
Bayer Corporation, Berkeley, CA (US);
Abstract
A method of selecting transfected cell lines for heterologous protein expression from a population of cells some of which include an endogenous sequence for an amplificable marker and some of which do not include the sequence. The method is based on a minimum amplifiability index which, contrary to current practice, focuses cell lines having relatively low productivity prior to amplification. Transfected cell lines selected with the instant invention produce greater amounts of heterologous protein than cells selected according to the prior art. In one embodiment, the amplifiability index is used to select for further amplification a cell line transfected with a vector containing the coding sequence for human Factor VIII.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile