Company Filing History:
9 out of 11 
3 out of 1,327 
1 out of 832,761 Years Active: 1993-2003
Title: Innovations by Inventor Shaji T George in Nucleic Acid Delivery
Introduction: Shaji T George is a prolific inventor based in New York, NY, with a remarkable portfolio boasting 13 patents. His groundbreaking work primarily revolves around efficient methodologies for the delivery of nucleic acids, with significant implications in the fields of medicine and biotechnology.
Latest Patents: Among his latest patents, Shaji T George has developed innovative methods for the delivery of nucleic acids using porphyrins. One such patent discusses efficient compositions for targeted delivery of nucleic acid molecules, including EGSs, ribozymes, and antisense oligonucleotides, specifically to hepatocytes. This method involves using a negatively charged oligonucleotide that binds to a positively charged macrocycle, such as a porphyrin, which protects and preferentially delivers the oligonucleotide to specific cells.
Additionally, another notable patent outlines the phenotypic conversion of bacterial cells mediated by external guide sequences. This method allows nucleic acids to be delivered to bacterial cells without requiring manipulation, making it suitable for natural environments. The technique leads to the conversion of drug-resistant bacterial cells into drug-sensitive cells, enhancing their susceptibility to drug therapy. Furthermore, Shaji's patents also encompass strategies for targeting eukaryotic pathogens and converting drug-resistant eukaryotic cells to drug-sensitive ones.
Career Highlights: Throughout his career, Shaji T George has been associated with noteworthy organizations including Innovir Laboratories, Inc. and Yale University. His extensive experience in these institutions has contributed to his innovative approach toward solving complex biological delivery challenges.
Collaborations: Collaborating with esteemed colleagues such as Allan R Goldberg and Garry B Takle, Shaji T George has fostered an environment of creativity and discovery. These collaborations have greatly enriched his research and have led to significant advancements in the field of nucleic acid delivery.
Conclusion: Shaji T George stands out as a crucial figure in the realm of biotechnology, particularly in the targeted delivery of nucleic acids. His innovative patents and collaborations underscore his commitment to overcoming the challenges posed by drug-resistant cells and enhancing therapeutic strategies. As he continues to embark on new projects, the scientific community eagerly anticipates his contributions to the field.