Company Filing History:
Years Active: 2025
Title: Innovations of Sethumadhavan Sankaran in Recombinant Human Insulin
Introduction
Sethumadhavan Sankaran is a notable inventor based in Bengaluru, India. He has made significant contributions to the field of biotechnology, particularly in the crystallization of recombinant human insulin. His innovative methods have the potential to enhance the manufacturing processes of this essential medication.
Latest Patents
Sankaran holds a patent for the "Preparative crystallization of recombinant human insulin." This invention discloses a method for crystallizing recombinant human insulin at both lab and manufacturing scales. The process involves the use of a mixture of zinc chloride and sodium chloride, along with a higher concentration of organic solvent (IPA-19 to 25 million). Additionally, the pH is adjusted to 5.0 at a faster rate of ≤5 minutes. The method also includes procedures that reduce settling time and alter holding temperature to facilitate consistent protein crystal formation between 15 μm-30 μm, thereby increasing the robustness of the process.
Career Highlights
Sethumadhavan Sankaran is associated with Biocon Limited, a leading biopharmaceutical company in India. His work at Biocon has allowed him to contribute to advancements in insulin production, which is crucial for diabetes management. His innovative approach to crystallization is a testament to his expertise in the field.
Collaborations
Sankaran has collaborated with notable colleagues such as Sandeep Vishwanath Kamath and Qais Shabandri. These collaborations have likely enriched his research and development efforts, leading to more effective solutions in biopharmaceutical manufacturing.
Conclusion
Sethumadhavan Sankaran's contributions to the field of recombinant human insulin crystallization exemplify the impact of innovation in biotechnology. His patent and work at Biocon Limited highlight the importance of advancements in medical science.