The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 30, 2025
Filed:
Jan. 09, 2020
Biocon Limited, Bangalore, IN;
Sethumadhavan Sankaran, Bengaluru, IN;
Sandeep Vishwanath Kamath, Bengaluru, IN;
Qais Shabandri, Bengaluru, IN;
Vibhava Shukla, Bengaluru, IN;
Arul Marimuthu, Thanjavur-DT, IN;
Ankita Saikia, Sivasagar, IN;
Sai Srikar Kandukuri, Guntur, IN;
Biocon Limited, Bangalore, IN;
Abstract
The present invention discloses a method for crystallizing recombinant Human Insulin at lab and manufacturing scale in the presence of zinc chloride and sodium chloride mixture, higher concentration of organic solvent (IPA-19 to 25 million) and adjusting the pH to 5.0 at a faster rate (≤5 minutes). The method further comprises adopting procedures wherein the settling time is reduced and the holding temperature is altered in order to facilitate consistent protein crystal formation between 15 μm-30 μm and to increase the robustness of the process.