Seth R Goldstein

Title: The Innovative Contributions of Seth R. Goldstein

Introduction

Seth R. Goldstein is a prominent inventor based in Bethesda, MD (US), known for his significant contributions to the field of laser capture microdissection. With a total of 15 patents to his name, Goldstein has developed innovative methods that enhance the precision and efficiency of cellular material extraction.

Latest Patents

Goldstein's latest patents include a method of laser capture microdissection from a sample utilizing short pulse length. This technique involves placing a transfer polymer film on a substrate that overlays visualized and selected cellular material from a sample for extraction. The transfer polymer film is activated with brief laser pulses, allowing for precise control over the melting process. This innovation minimizes thermal diffusion into surrounding non-irradiated polymer, ensuring that only the targeted area is affected. Additionally, he has developed a method for isolating cellular material under microscopic visualization, which involves forming an image field of cells, identifying zones of interest, and extracting them using a selectively activatable transfer surface.

Career Highlights

Throughout his career, Seth R. Goldstein has worked with esteemed organizations, including the National Institutes of Health, a component of the US Department of Health & Human Services. His work has significantly advanced the field of microdissection, providing researchers with powerful tools for cellular analysis.

Collaborations

Goldstein has collaborated with notable colleagues such as Robert F. Bonner and Paul D. Smith, contributing to the development of innovative techniques in his field.

Conclusion

Seth R. Goldstein's contributions to laser capture microdissection exemplify the impact of innovation in scientific research. His patents and collaborative efforts continue to influence the methodologies used in cellular analysis today.