Location History:
- Boulder, CO (US) (1983)
- Mountain View, CA (US) (1987 - 1994)
Company Filing History:
Years Active: 1983-1994
Title: The Innovative Contributions of Serge L Beaucage
Introduction
Serge L Beaucage is a notable inventor based in Mountain View, CA (US), recognized for his significant contributions to the field of biochemistry and molecular biology. With a total of 4 patents to his name, Beaucage has made strides in the synthesis of nucleotides and related compounds.
Latest Patents
Among his latest patents is a process for terminal substituting of a polynucleotide. This method involves substituting a substitution compound for the hydrogen of a support bound primary hydroxyl group. The process utilizes an organic, substantially anhydrous solvent in the presence of a tertiary amine base and the substitution compound, which contains both a positive moiety and a negative moiety. The positive moiety is selected from trityl, pixyl, and their derivatives. The reagent used in this process includes tetraalkylammonium salts and inorganic salts, ensuring that the cation moiety of the reagent is more electropositive than the positive moiety of the substitution compound. This relationship allows the reagent to attract the negative moiety of the substitution compound.
Another significant patent by Beaucage is for a process of oligonucleotide synthesis using phosphoramidite intermediates. This innovation introduces a new class of nucleoside phosphoramidites that are relatively stable, allowing for their isolation and storage at room temperature. These phosphoramidites are derivatives of saturated secondary amines, showcasing Beaucage's commitment to advancing the field of nucleotide chemistry.
Career Highlights
Throughout his career, Serge L Beaucage has worked with esteemed organizations such as University Patents, Inc. and Beckman Instruments, Inc. His work has had a lasting impact on the development of new methodologies in the synthesis of nucleotides and related compounds.
Collaborations
Beaucage has collaborated with notable figures in the field, including Marvin H Caruthers and Paramesewara M Reddy. These collaborations have further enriched his research and contributions to the scientific community.
Conclusion
Serge L Beaucage's innovative work in the field of biochemistry has led to significant advancements in nucleotide synthesis. His patents reflect a deep understanding of molecular interactions and a commitment to scientific progress.