Serge D Negra

Title: The Innovative Contributions of Serge D Negra

Introduction

Serge D Negra is a notable inventor based in Chilly Mazarin, France. He has made significant contributions to the field of biological sample analysis, holding a total of 3 patents. His work focuses on enhancing the understanding of biological tissues through advanced techniques.

Latest Patents

One of his latest patents is titled "Gold implantation/deposition of biological samples for laser desorption two and three dimensional depth profiling of biological tissues." This invention improves the laser desorption of biological molecular ions from surfaces by creating a surface-localized MALDI particle matrix. This is achieved through ion implantation of low-energy ionized clusters, such as gold and aluminum, into the near-surface region of the sample. The MALDI analysis allows for the examination of intact biomolecules on the surface or within a narrow subsurface region defined by the implantation range of the ions. This process can be performed by laser desorption into a mass spectrometer or, preferably, into a combined ion mobility orthogonal time-of-flight mass spectrometer.

Another significant patent involves a time-of-flight mass spectrometer. This device includes an ion source, an ion mirror, and two detectors, all arranged in an assembly of axial symmetry. The spectrometer is designed to obtain a reflex spectrum of the ions reflected by the mirror, while also capturing a spectrum of neutral species that may result from in-flight decompositions of metastable ions. This innovative arrangement is particularly suited for studying metastable ions, with processing means provided to produce correlated reflex spectra.

Career Highlights

Throughout his career, Serge D Negra has worked with esteemed organizations, including the Centre National de la Recherche Scientifique and Ionwerks, Inc. His experience in these institutions has allowed him to develop and refine his innovative techniques in biological analysis.

Collaborations

Serge has collaborated with notable individuals in his field, including Yvon Le Beyec and J Albert Schultz. These partnerships have contributed to the advancement of his research and inventions.

Conclusion

Serge D Negra's contributions to the field of biological sample analysis through his innovative patents demonstrate his commitment to advancing scientific understanding. His work continues to influence the study of biological tissues and molecular analysis.