This inventor holds 2 USPTO granted patents and 1 EPO patent. Top assignee: University System of Maryland. Active years: 2020-2026.
Company Filing History:
Years Active: 2020-2026
Title: Innovations in Dermatological Treatments by Senthilmurugan Ramalingam
Introduction
Senthilmurugan Ramalingam is an accomplished inventor based in Baltimore, MD (US). He has made significant contributions to the field of dermatology through his innovative research and development of novel retinamides. With a total of 2 patents, his work focuses on treating various dermatological disorders and cancers.
Latest Patents
One of his latest patents is titled "Composition and method for treating dermatological disorders using retinamides." This invention involves the synthesis and development of unique retinamides that inhibit retinoic acid metabolism and modulate Mnk1/2-eIF4E and androgen receptor (AR) signaling pathways. These novel retinamides are designed to treat a variety of dermatological conditions while minimizing adverse side effects.
Another significant patent is "13-cis-RAMBA retinamides that degrade MNKs for treating cancer." This patent discusses the synthesis and in vitro and in vivo anti-breast and anti-prostate cancer activities of novel C-4 heteroaryl 13-cis retinamides. These compounds effectively induce Mnk1/2 degradation, substantially suppressing eIF4E phosphorylation in both breast and prostate cancer cell lines. Additionally, they induce degradation of both full-length androgen receptor (fAR) and splice variant AR (AR-V7), inhibiting AR transcriptional activity. The multiple activities of these compounds result in the inhibition of cell growth and migration, as well as the induction of apoptosis, demonstrating strong anti-cancer activities without apparent host toxicities.
Career Highlights
Senthilmurugan Ramalingam is affiliated with the University System of Maryland, where he continues to advance his research in dermatological treatments and cancer therapies. His innovative work has garnered attention in the scientific community, contributing to the development of effective treatment options.
Collaborations
He collaborates with notable colleagues, including Vidya P Ramamurthy and Hannah W Mbatia, to further enhance the impact of his research.
Conclusion
Senthilmurugan Ramalingam's contributions to dermatological treatments and cancer therapies through his innovative patents highlight the importance of research in improving health outcomes. His work exemplifies the potential of novel compounds in addressing complex medical challenges.