Company Filing History:
Years Active: 2010-2022
Title: Scott M Kee: Innovator in Alpha-1-Antitrypsin Purification
Introduction
Scott M Kee is a notable inventor based in Bourbonnais, IL (US). He has made significant contributions to the field of biochemistry, particularly in the purification of alpha-1-antitrypsin (AAT). With a total of 7 patents to his name, Kee's work has the potential to impact pharmaceutical processes significantly.
Latest Patents
One of Kee's latest patents focuses on methods of treatment using alpha-1-antitrypsin compositions. This innovative method streamlines the purification of AAT from an AAT-containing protein mixture, such as Coh fraction IV precipitate. The process involves destabilizing contaminating proteins by cleaving disulfide bonds with a reducing reagent, such as dithiol, which does not affect AAT. The destabilized proteins are preferentially adsorbed on a solid protein-adsorbing material, eliminating the need for salt as a precipitant. The separation of the solid absorbent from the solution results in a purified AAT solution that is directly suitable for chromatographic purification, without extensive desalting as required in prior art processes. This method provides pharmaceutical-grade AAT in high yield on a commercial scale.
Career Highlights
Throughout his career, Scott M Kee has worked with prominent companies in the biopharmaceutical industry, including CSL Behring LLC and CSL Behring GmbH. His experience in these organizations has contributed to his expertise in the field of protein purification and treatment methods.
Collaborations
Kee has collaborated with notable professionals in his field, including Paul I Cook and James R Smith. These collaborations have likely enriched his research and development efforts, leading to innovative solutions in AAT purification.
Conclusion
Scott M Kee's contributions to the field of alpha-1-antitrypsin purification demonstrate his commitment to advancing biopharmaceutical processes. His innovative methods and collaborations highlight the importance of teamwork in achieving significant breakthroughs in science.