Location History:
- Maharashtra, IN (2010)
- Wadala, IN (2011)
Company Filing History:
1 out of 2 
1 out of 31 
Years Active: 2010-2011
Title: The Innovative Contributions of Satish Mahadeorao Totey
Introduction
Satish Mahadeorao Totey is a notable inventor based in Wadala, India. He has made significant contributions to the field of stem cell research, holding 2 patents that showcase his innovative spirit and dedication to advancing medical science.
Latest Patents
One of his latest patents is titled "Pluripotent embryonic-like stem cells derived from corneal limbus, methods of isolation and uses thereof." This patent describes mammalian pluripotent embryonic-like stem cells (ELSCs) isolated from corneal limbal tissue, which is a non-embryonic tissue. The ELSCs are capable of proliferating in an in vitro culture and maintain the potential to differentiate into cells of endoderm, mesoderm, and ectoderm lineage. They can also form embryoid-like bodies when placed in suspension culture, indicating their multi-lineage differentiation potential and self-renewing capability. These cells may serve as a promising therapeutic tool, providing new alternatives for various diseases, conditions, and injuries.
Another significant patent by Totey is focused on the "Derivation of terminally differentiated dopaminergic neurons from human embryonic stem cells." This patent outlines improved methods for efficiently producing neuroprogenitor cells and differentiated neural cells, such as dopaminergic and serotonergic neurons, from pluripotent stem cells. The methods disclosed allow for the isolation of cell populations with a high proportion of cells positive for tyrosine hydroxylase, a specific marker for dopaminergic neurons. The neuroprogenitor cells and terminally differentiated cells generated can be produced in large quantities, making them an excellent source for cell replacement therapy in neurological disorders like Parkinson's disease.
Career Highlights
Totey has worked with Reliance Life Sciences Pvt. Ltd., where he has contributed to groundbreaking research in the field of stem cells. His work has been instrumental in advancing the understanding and application of stem cell technology in medicine.
Collaborations
Throughout his career, Totey has collaborated with esteemed colleagues such as Geeta Ravindran and Subhadra Devi Kashyap. These collaborations have further enriched his research and contributed to the success of his innovative projects.
Conclusion
Satish Mahadeorao Totey's contributions to stem cell research and his innovative