Reliance Life Sciences Pvt. Ltd.

Reliance Life Science Pvt. Ltd.

Satish Mahadeorao Totey

Geeta Ravindran

Khan Firdos Alam

Pai Rajarshi

Subhadra Devi Kashyap

Khanna Aparna

Tipnis Shabri

The present disclosure describes mammalian pluripotent embryonic-like stem cells (ELSCs) isolated from corneal limbal tissue, a non-embryonic tissue. The ELSCs of the present disclosure are capable of proliferating in an in vitro culture, maintain the potential to differentiate into cells of endoderm, mesoderm, and ectoderm lineage in culture, and are capable of forming embryoid-like bodies when placed in suspension culture. Thus, these cells possess multi-lineage differentiation potential and self-renewing capability. ELSCs may be a promising therapeutic tool, and may provide new therapeutic alternatives for various diseases, conditions, and injuries.

Pluripotent embryonic-like stem cells derived from corneal limbus, methods of isolation and uses thereof

The present disclosure is directed to improved methods for efficiently producing neuroprogenitor cells and differentiated neural cells such as dopaminergic neurons and serotonergic neurons from pluripotent stem cells, for example human embryonic stem cells. Using the disclosed methods, cell populations containing a high proportion of cells positive for tyrosine hydroxylase, a specific marker for dopaminergic neurons, have been isolated. The neuroprogenitor cells and terminally differentiated cells of the present disclosure can be generated in large quantities, and therefore may serve as an excellent source for cell replacement therapy in neurological disorders such as Parkinson's disease.

Derivation of terminally differentiated dopaminergic neurons from human embryonic stem cells

Growing community of inventors

Wadala, India

Satish Mahadeorao Totey