Company Filing History:
1 out of 3,580 
1 out of 10,754 
1 out of 832,843 Years Active: 1996-2015
Title: Innovations by Sanford Jay Silverman
Introduction
Sanford Jay Silverman is an accomplished inventor based in Roosevelt, NJ (US). He holds a total of 3 patents that showcase his contributions to the field of biotechnology. His work primarily focuses on gene expression and protein depletion in yeast, which has significant implications for research and development in various scientific domains.
Latest Patents
One of his latest patents is titled "Systems for induction of gene expression and protein depletion in yeast." This innovative system allows for rapid and specific induction of individual genes in eukaryotic cells using a chimeric transcriptional activator that responds to a hormone inducer. Upon the addition of the hormone, the cytoplasmic transcriptional activator localizes to the nucleus and binds to specific promoters. This genetic modification enables the rapid degradation of targeted proteins, facilitating high throughput screening for new compounds when introducing compound libraries to protein-depleted cells.
Another significant patent is the "Calcafluor screen for chitin biosynthesis inhibitors." This method identifies agents that inhibit chitin synthesis, which may exhibit fungicidal and insecticidal activity. The process involves incubating test samples in neutral cultures containing calcofluor white, a fluorochrome that induces lethal chitin hyper-polymerization in yeast. The growth of cultures containing samples that inhibit chitin synthesis is enhanced, demonstrating the potential of this method in discovering new agricultural agents.
Career Highlights
Throughout his career, Sanford Jay Silverman has worked with notable organizations, including the American Cyanamid Company. His experience in these companies has contributed to his expertise in biotechnology and innovation.
Collaborations
Some of his notable coworkers include Robert Scott McIsaac and Marcus Noyes. Their collaborations have likely enriched the research environment and fostered innovative solutions in their respective fields.
Conclusion
Sanford Jay Silverman is a prominent inventor whose work in gene expression and protein depletion has paved the way for advancements in biotechnology. His patents reflect a commitment to innovation and the potential for significant contributions to scientific research.