Company Filing History:
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Years Active: 1995-2000
Title: Inventor Samuel I Miller, III: Innovations in Salmonella Research
Introduction
Samuel I Miller, III is an accomplished inventor based in Brookline, MA, recognized for his significant contributions to the field of microbiology, particularly in researching Salmonella. With a total of eight patents to his name, Miller's work has paved the way for advancements in understanding virulence and developing potential therapeutic strategies.
Latest Patents
Among his recent innovations, Miller has been credited with patents that focus on Salmonella virulence genes. One notable patent describes a vector capable of integrating into the chromosome of Salmonella, which includes a DNA sequence encoding a heterologous protein, a marker, and a phoP regulatory region. This vector is essential for understanding the mechanisms of virulence, with the third DNA sequence being mutationally inactivated to modulate its effects.
Another significant patent involves modified Salmonella where the wild type pag gene has been replaced with a gene encoding a truncated pag gene fused to a heterologous DNA segment. This modification significantly reduces Salmonella's virulence while enabling the generation of immune reactions to the fusion protein's heterologous gene portion. Furthermore, the patent details potential applications of this vector, including its use in drug screening processes.
Career Highlights
Throughout his career, Samuel I Miller, III has collaborated with reputable organizations such as The General Hospital Corporation and the President and Fellows of Harvard College. His work has significantly impacted research on infectious diseases, particularly through his innovations in Salmonella research.
Collaborations
Miller has worked alongside prominent figures in his field, including John J Mekalanos and Michael E Selsted. These collaborations have further advanced research efforts and provided valuable insights into the understanding of pathogenic organisms.
Conclusion
Samuel I Miller, III is a notable inventor whose research in Salmonella has led to several important patents. His innovative approaches to understanding virulence and developing therapeutic strategies mark significant progress in microbiology. As he continues his work, Miller's contributions are expected to have lasting impacts on medical research and public health.