Company Filing History:
9 out of 1,217 
2 out of 3,539 
1 out of 1 Years Active: 1987-2016
Title: Innovations of Samuel Broder in HIV and Hepatitis B Research
Introduction
Samuel Broder is a prominent inventor based in Bethesda, MD (US), known for his significant contributions to the field of virology. He holds a total of 13 patents, focusing primarily on vaccines and methods for the prevention and treatment of drug-resistant viruses, particularly HIV-1 and hepatitis B.
Latest Patents
One of his latest patents involves vaccines and methods for the prevention and treatment of drug-resistant HIV-1 and hepatitis B virus. This invention provides methods for lowering the viral load of a virus resistant to antiviral drugs by inducing cytotoxic T lymphocytes (CTL) to recognize a predetermined mutated epitope within a viral protein of the drug-resistant virus. CTLs are induced by immunizing a host with a peptide that comprises the predetermined mutation. The immunostimulating peptide may be further improved by epitope-enhancement for inducing specific CTLs. The antiviral protection against drug-resistant viruses shown by the compositions of this invention, mediated by human HLA-restricted CTL, has not been previously achieved. Another notable patent is a method of inhibiting HIV replication with 2',3'-dideoxyadenosine. This method involves inhibiting intracellular replication of HIV in an HIV-infected individual by contacting the HIV reverse transcriptase in the HIV-infected cells with 2',3'-dideoxyadenosine-5'-triphosphate, sourced from 2',3'-dideoxyadenosine or a pharmaceutically acceptable salt or prodrug thereof.
Career Highlights
Throughout his career, Samuel Broder has made substantial contributions to the understanding and treatment of viral infections. His work has been instrumental in developing innovative approaches to combat drug-resistant strains of HIV and hepatitis B.
Collaborations
Samuel Broder has collaborated with notable figures in the field, including Hiroaki Mitsuya and Robert Yarchoan. These collaborations have further advanced research and development in antiviral therapies.
Conclusion
Samuel Broder's innovative work in the field of virology has led to significant advancements in the treatment of drug-resistant HIV and hepatitis B. His contributions continue to impact the medical community and improve patient outcomes.