The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 25, 2016
Filed:
Feb. 22, 2006
Andrew Catanzaro, Washington, DC (US);
Robert Yarchoan, Bethesda, MD (US);
Jay A. Berzofsky, Bethesda, MD (US);
Takahiro Okazaki, Yokohama, JP;
James T. Snyder, Ii, Phoenix, AZ (US);
Samuel Broder, Bethesda, MD (US);
Andrew Catanzaro, Washington, DC (US);
Robert Yarchoan, Bethesda, MD (US);
Jay A. Berzofsky, Bethesda, MD (US);
Takahiro Okazaki, Yokohama, JP;
James T. Snyder, II, Phoenix, AZ (US);
Samuel Broder, Bethesda, MD (US);
Abstract
The present invention provides methods for lowering a viral load of a virus resistant to an antiviral drug by inducing cytotoxic T lymphocytes (CTL) to recognize a predetermined mutated epitope within a viral protein of the drug-resistant virus. CTLs are induced by immunizing a host with a peptide comprising the predetermined mutation. The immunostimulating peptide may be further improved by epitope-enhancement for inducing specific CTLs. The antiviral protection against drug-resistant virus shown by compositions of the present invention and mediated by human HLA-restricted CTL has not been previously achieved.