S B Jennifer Kan

Title: S B Jennifer Kan: Innovator in Organosilicon Compounds and Biocatalytic Synthesis

Introduction

S B Jennifer Kan is a prominent inventor based in Pasadena, California, known for her significant contributions to the field of organosilicon compounds and biocatalytic synthesis. With a total of three patents to her name, she has made remarkable advancements in the preparation of silanol-functional organosilicon compounds and the production of strained carbocycles.

Latest Patents

One of her latest patents is titled "Method of preparing silanols with selective cytochrome P450 variants and related compounds and compositions." This patent discloses a method for preparing a silanol-functional organosilicon compound using a cytochrome P450 variant. The method facilitates the oxidation of a silyl hydride group to a silanol group in the presence of oxygen. It involves combining the cytochrome P450 variant with an organosilicon compound that has at least one silicon-bonded hydrogen atom, followed by exposure to oxygen to oxidize the compound. The patent also includes details on suitable cytochrome P450 variants, methods for engineering and optimizing them, as well as nucleic acids encoding these variants.

Another significant patent is focused on the "Biocatalytic synthesis of strained carbocycles." This patent provides methods for producing products containing strained carbocycles, such as cyclopropene and bicyclobutane moieties. The methods involve combining an alkyne and a carbene precursor in the presence of a heme protein, such as a cytochrome P450, under conditions that allow for the formation of the strained carbocycle. The patent also describes reaction mixtures and whole-cell catalysts that can be used for producing these compounds.

Career Highlights

S B Jennifer Kan has worked with esteemed organizations, including the California Institute of Technology and Dow Silicones Corporation. Her work in these institutions has allowed her to develop innovative methods and contribute to advancements in her field.

Collaborations

Throughout her career, she has collaborated with notable colleagues, including Kai Chen and Xiongyi Huang. These collaborations have further enriched her research and development efforts.

Conclusion

S B Jennifer Kan is a trailblazer in the field of organosilicon compounds and biocatalytic synthesis, with a strong portfolio of patents that