Company Filing History:
2 out of 789 
1 out of 70 Years Active: 1984-1990
Title: Ryotaro Kotani: Innovator in Biotechnology
Introduction
Ryotaro Kotani is a notable inventor based in Moriyama, Japan. He has made significant contributions to the field of biotechnology, particularly in the development of processes and compositions that enhance medical treatments. With a total of 2 patents, his work has the potential to impact various therapeutic applications.
Latest Patents
One of Kotani's latest patents is a process for producing tissue plasminogen activator (tPA). This invention outlines a method that involves cultivating Escherichia coli, yeast, or mammalian cells that have been genetically modified to include the gene for human tPA. The process incorporates the use of a specific antiplasmin agent during cultivation or purification to prevent the conversion of single-chain tPA into double-chain tPA by proteases present in the medium. Another significant patent is for a stable enzyme composition that includes glutathione peroxidase along with stabilizer compounds such as pentoses, hexoses, and disaccharides. This composition aims to enhance the stability and efficacy of the enzyme for various applications.
Career Highlights
Throughout his career, Ryotaro Kotani has worked with prominent companies in the biotechnology sector. He has been associated with Toyo Boseki Kabushiki Kaisha and Daiichi Seiyaku Co., Ltd., where he has contributed to various innovative projects. His expertise in recombinant DNA technology and enzyme stabilization has positioned him as a valuable asset in the industry.
Collaborations
Kotani has collaborated with esteemed colleagues, including Setsuo Kobayashi and Kazuo Beppu. These partnerships have fostered a collaborative environment that encourages innovation and the sharing of ideas in the field of biotechnology.
Conclusion
Ryotaro Kotani's contributions to biotechnology through his patents and collaborations highlight his role as an influential inventor. His work continues to pave the way for advancements in medical treatments and enzyme applications.