Location History:
- Dartmouth, CA (2010)
- Mineville, CA (2012 - 2022)
Company Filing History:
Years Active: 2010-2025
Title: Roy Duncan: Innovator in Membrane Fusion and Oncolytic Viruses
Introduction
Roy Duncan is a notable inventor based in Mineville, California. He holds a total of 6 patents that showcase his contributions to the fields of biotechnology and medicine. His innovative work primarily focuses on recombinant polypeptides and oncolytic viruses, which have significant implications for cancer treatment and cellular processes.
Latest Patents
One of Roy Duncan's latest patents is titled "Recombinant polypeptides for membrane fusion and uses thereof." This invention discloses a recombinant polypeptide designed to facilitate membrane fusion. The polypeptide features a sequence with at least 80% identity to the ectodomain of the p14 fusion-associated small transmembrane (FAST) protein, along with a functional myristoylation motif and a transmembrane domain from a FAST protein. Additionally, a targeting ligand can be incorporated into the recombinant polypeptide for selective fusion. This polypeptide can be utilized in liposome membranes to deliver bioactive compounds, such as siRNA, or mixed with a lipid carrier to induce cell-cell fusion and heterokaryon formation.
Another significant patent is "Recombinant oncolytic viruses for treatment of metastatic cancers." This invention involves recombinant oncolytic viruses that express one or more reovirus FAST proteins. The oncolytic activity of these viruses can be harnessed to treat both primary and metastatic cancers, particularly breast and colon cancers.
Career Highlights
Throughout his career, Roy Duncan has worked with various companies, including Entos Pharmaceuticals Inc. and Innovascreen, Inc. His work in these organizations has contributed to advancements in therapeutic technologies and innovative solutions in the medical field.
Collaborations
Roy Duncan has collaborated with notable individuals in his field, including Eileen Kathryn Clancy and Roberto Justo De Antueno. These collaborations have likely enriched his research and development efforts, leading to impactful innovations.
Conclusion
Roy Duncan's contributions to the fields of biotechnology and medicine through his patents and collaborations highlight his role as an influential inventor. His work continues to pave the way for advancements in cancer treatment and cellular technology.