Rosemarie H De Kruyff

Title: Innovations and Contributions of Rosemarie H De Kruyff

Introduction

Rosemarie H De Kruyff is a notable inventor based in Newton, MA, who has made significant contributions to the field of medical research. With a total of two patents to her name, her work primarily focuses on innovative methods for treating and preventing various diseases.

Latest Patents

One of her latest patents is titled "Compositions and methods for inhibiting viral entry." This invention provides methods, compositions, and kits featuring agents that inhibit viral entry mediated by T-cell Immunoglobulin and Mucin-domain containing proteins (TIM proteins) and other phosphatidylserine receptors. Another significant patent is "Methods for the treatment and prevention of inflammatory diseases." In this patent, the inventors demonstrate that treatment of young, suckling mice with a glycolipid derived from activates NKT cells in a CD1d-restricted fashion, which is protective against airway hyperreactivity in a model of allergen-induced asthma. The findings indicate that this protective effect can be transferred by NKT cells exposed to the glycolipid and is associated with the expansion of suppressive double-negative NKT cells and Foxp3 T cells. Furthermore, the inventors show that pre-treatment of adult mice with a glycolipid derived from partially suppresses airway hyperreactivity and inhibits BAL inflammation in an ozone-exposure model. Accordingly, the patent provides compositions and methods for the treatment and prevention of inflammatory diseases, such as asthma or autoimmune diseases, in subjects in need thereof.

Career Highlights

Throughout her career, Rosemarie has worked with esteemed organizations, including the Children's Medical Center Corporation and Dana-Farber Cancer Institute. Her work in these institutions has allowed her to contribute to groundbreaking research in immunology and inflammatory diseases.

Collaborations

Rosemarie has collaborated with notable colleagues, including Dale T Umetsu and Hyeryun Choe, which has further enriched her research and innovations.

Conclusion

Rosemarie H De Kruyff's contributions to medical research through her patents and collaborations highlight her dedication to advancing healthcare solutions. Her innovative approaches to treating viral infections and inflammatory diseases continue to impact the field positively.