The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 2017
Filed:
May. 24, 2011
Dale T. Umetsu, Newton, MA (US);
Rosemarie H. DE Kruyff, Newton, MA (US);
Ya-jen Chang, Brookline, MA (US);
Petr Illarionov, Birmingham, GB;
Dale T. Umetsu, Newton, MA (US);
Rosemarie H. De Kruyff, Newton, MA (US);
Ya-Jen Chang, Brookline, MA (US);
Petr Illarionov, Birmingham, GB;
Children's Medical Center Corporation, Boston, MA (US);
University of Birmingham, Birmingham, GB;
Abstract
The inventors demonstrate that treatment of young, suckling mice with a glycolipid derived fromactivates NKT cells in a CD1d-restricted fashion, and is protective against AHR in a model of allergen-induced asthma. The inventors further found that this protective effect can be transferred by NKT cells exposed to the glycolipid, and is associated with the expansion of a suppressive double-negative NKT cells and Foxp3Tcells. The inventors also demonstrate herein that pre-treatment of adult mice with a glycolipid derived frompartially suppresses airway hyperreactivity and inhibits BAL inflammation in an ozone-exposure model. Accordingly, provided herein are compositions and methods for the treatment and prevention of inflammatory diseases, such as asthma or autoimmune diseases, in a subject in need thereof.