Rosario Silvestre Castillo

This inventor holds 13 USPTO granted patents. Top assignees: Texas Biotechnology Corporation, Immunopharmaceutics, Inc.. Active years: 1995-2003.

IDiyas Innovation Intelligence. (2026). Inventor Profile: Rosario Silvestre Castillo. Retrieved from https://idiyas.com/inventor/rosario-silvestre-castillo

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Calculating rank

USPTO Granted Patents = 13

% Patents Active = 100.0

Average Co-Inventor Count = 7.7

ph-index = 11

Forward Citations = 397(Granted Patents)

Company Filing History:

11 out of 37

Texas Biotechnology Corporation

patents

2 out of 3

Immunopharmaceutics, Inc.

patents

Years Active: 1995-2003

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13 patents (USPTO):Sort by Forward CitationsExplore Patents

1. 6541498 - Benzenesulfonamides and the use thereof to modulate the activity of endothelin (2003-04-01),

2. 6376523 - Benzenesulfonamides and the use thereof to modulate the activity of endothelin (2002-04-23),

3. 6342610 - N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin (2002-01-29),

4. 6331637 - N-Alkyl, N-Alkenyl, N-Alkynyl, N-Aryl and N-fused bicyclo or tricyclo thienyl-, furyl-,and Pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin (2001-12-18),

5. 6265428 - Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin (2001-07-24),

6. 6030991 - Benzenesulfonamides and the use thereof to modulate the activity of (2000-02-29),

7. 5977117 - Substituted phenyl compounds and derivatives thereof that modulate the (1999-11-02),

8. 5962490 - Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that (1999-10-05),

9. 5594021 - Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that (1997-01-14),

10. 5591761 - Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof (1997-01-07),

11. 5571821 - Sulfonamides and derivatives thereof that modulate the activity of (1996-11-05),

12. 5514691 - N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate (1996-05-07),

13. 5464853 - N-(5-isoxazolyl)biphenylsulfonamides, (1995-11-07),

Title: Innovations of Rosario Silvestre Castillo

Introduction

Rosario Silvestre Castillo is a prominent inventor based in San Diego, California. He holds a total of 13 patents, showcasing his significant contributions to the field of biotechnology and pharmaceuticals. His work primarily focuses on the modulation of endothelin activity, which has implications for treating various inflammatory diseases.

Latest Patents

Among his latest patents are innovative compounds such as N-(5-isoxazolyl)benzenesulfonamides and N-(3-isoxazolyl)benzenesulfonamides. These compounds are designed to modulate the activity of the endothelin family of peptides. Specifically, they provide methods for inhibiting the binding of endothelin peptides to their receptors or enhancing their activity. N-isoxzolyl-4-biphenylsulfonamides are particularly noted for their effectiveness as endothelin receptor B antagonists. Castillo's patents also include methods for treating endothelin-mediated disorders, particularly inflammatory diseases like asthma, by administering effective amounts of these sulfonamides or their prodrugs.

Career Highlights

Throughout his career, Rosario Silvestre Castillo has worked with notable companies such as Texas Biotechnology Corporation and Immunopharmaceutics, Inc. His experience in these organizations has contributed to his expertise in developing innovative therapeutic solutions.

Collaborations

Some of his notable coworkers include Ming Fai Chan and Bore G Raju, who have collaborated with him on various projects, enhancing the scope and impact of his inventions.

Conclusion

Rosario Silvestre Castillo's contributions to the field of biotechnology through his patents and collaborations highlight his role as a significant innovator. His work continues to influence the development of treatments for inflammatory diseases, showcasing the importance of innovation in healthcare.

Profile summary based on public USPTO records.

Data Sources: USPTO Patent Grant XML, Patent Center, EPO & CIPO • Normalized by IDiyas Innovation Graph. Methodology & provenance architecturePlease report any incorrect information to [email protected]