The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 29, 2002
Filed:
Nov. 07, 1997
Ming Fai Chan, San Diego, CA (US);
Chengde Wu, Houston, TX (US);
Bore Gowda Raju, Sugar Land, TX (US);
Timothy Kogan, Sugar Land, TX (US);
Erik Joel Verner, Foster City, CA (US);
Rosario Silvestre Castillo, San Diego, CA (US);
Venkatachalapathi Yalamoori, San Diego, CA (US);
Adam Kois, San Diego, CA (US);
Vitukudi Narayanaiyengar Balaji, Encinitas, CA (US);
Texas Biotechnology Corp., Houston, TX (US);
Abstract
Thienyl-, furyl- and pyrrolyl-sulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thienylsulfonamides, N-(isoxazolyl)furylsulfonamides and N-(isoxazolyl)pyrrolylsulfonamides and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelin are also provided.