Company Filing History:
Years Active: 2015-2024
Title: The Innovative Contributions of Ron B Shmueli
Introduction
Ron B Shmueli is a prominent inventor based in Baltimore, MD, known for his significant contributions to the field of biomedical engineering. With a total of 8 patents to his name, Shmueli has made remarkable advancements in the development of materials for gene delivery and cancer treatment. His work is characterized by a commitment to improving therapeutic options for patients suffering from various diseases.
Latest Patents
One of Shmueli's latest patents involves the creation of multicomponent degradable cationic polymers. These polymers are synthesized to self-assemble with DNA, forming particles that are effective for gene delivery. Notably, small modifications in polymer synthesis conditions and structure can lead to significant changes in efficacy, particularly in a cell-type dependent manner. The polymers he developed have shown to be more effective than commercially available materials, such as LIPOFECTAMINE 2000™, FUGENE®, or polyethylenimine (PEI), especially for gene delivery to cancerous fibroblasts and human primary fibroblasts. This innovation holds promise for applications in cancer therapeutics and regenerative medicine.
Another significant patent focuses on a biomimetic peptide and biodegradable delivery platform aimed at treating diseases dependent on angiogenesis and lymphangiogenesis. This patent discloses mimetic peptides with anti-angiogenic and anti-tumorigenic properties. The isolated peptide, which includes the amino acid sequence LRRFSTAPFAFIDINDVINF, demonstrates anti-angiogenic activity in various assays and shows potential for treating cancer and ocular diseases, such as age-related macular degeneration. The peptide also exhibits anti-lymphangiogenic and directly anti-tumorigenic properties, making it a valuable asset in the fight against cancer.
Career Highlights
Throughout his career, Ron B Shmueli has worked with esteemed institutions, including The Johns Hopkins University and Asclepix Therapeutics, Inc. His research has significantly impacted the field of biomedical engineering, particularly in the development of innovative materials for medical applications.
Collaborations
Shmueli has collaborated with notable professionals in his field, including Jordan J Green and Aleksander S Popel. These collaborations have further enhanced the scope and impact of his research.
Conclusion
Ron B Shmueli's innovative work in the development of
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