Company Filing History:
Years Active: 2010-2012
Title: Innovations by Rodney Kiplin Guy
Introduction
Rodney Kiplin Guy is an accomplished inventor based in Concord, CA (US). He has made significant contributions to the field of molecular biology, particularly in the area of PDZ-domain interactions. With a total of 2 patents, his work has implications for cancer research and therapeutic development.
Latest Patents
Rodney's latest patents focus on small molecule inhibition of PDZ-domain interactions. These novel compounds have been found effective in inhibiting interactions of PDZ domains in MAGIs with the oncogenic protein PTEN. Additionally, they target interactions between the PDZ domain in the Dishevelled (Dvl) protein and other proteins such as the Frizzled (Fz) protein. The inventions include combinatorial libraries, arrays, and methods for screening and studying proteins using these compounds. Notably, the compounds have produced apoptosis in certain cell lines that overexpress the Dishevelled protein, thereby inhibiting Wnt signaling.
Career Highlights
Rodney is affiliated with the University of California, where he continues to advance his research and innovation in molecular biology. His work has garnered attention for its potential applications in cancer treatment and understanding cellular signaling pathways.
Collaborations
Rodney has collaborated with notable colleagues, including Naoaki Fujii and Liang You. These partnerships have contributed to the depth and breadth of his research endeavors.
Conclusion
Rodney Kiplin Guy's innovative work in the field of PDZ-domain interactions exemplifies the impact of scientific research on potential cancer therapies. His contributions continue to shape the landscape of molecular biology and therapeutic development.