The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 14, 2010
Filed:
Jun. 30, 2005
Rodney Kiplin Guy, Concord, CA (US);
Naoaki Fujii, South San Francisco, CA (US);
Liang You, San Francisco, CA (US);
David M. Jablons, San Francisco, CA (US);
Rodney Kiplin Guy, Concord, CA (US);
Naoaki Fujii, South San Francisco, CA (US);
Liang You, San Francisco, CA (US);
David M. Jablons, San Francisco, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl) protein and other proteins such as the Frizzled (Fz) protein, have the general formula (I) or (III) The invention also includes combinatorial libraries, arrays and methods for screening and studying proteins using such compounds. Compounds of the invention have produced apoptosis in certain cell lines that overexpress the Dishevelled protein (Dvl), inhibiting Wnt signaling.