This inventor holds 1 USPTO granted patent and 1 published patent application. Top assignee: Schering Corporation. Active years: 2010.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 2010
Title: The Innovations of Robert Orville Ralston, II
Introduction
Robert Orville Ralston, II is a notable inventor based in Union, NJ (US). He has made significant contributions to the field of biotechnology, particularly in the development of cell lines for the production of adenovirus vectors. His work has implications for gene therapy and vaccine development.
Latest Patents
Ralston holds a patent for "Cell lines for production of replication-defective adenovirus." This invention provides cell lines for the production of E1-deleted adenovirus (rAd) vectors that complement E1A and E1B functions. Additionally, it includes cell lines for the production of E1- and E2-deleted adenovirus vectors that complement E1A, E1B, and E2B polymerase functions. The invention features specific cell lines that enhance E1A function through the insertion of an E1A sequence with mutations in the 243R and 289R proteins, along with an E1B sequence comprising the E1B-55K gene. The production yields from the resulting producer cell lines, designated SL0003 and SL0006, were comparable to those obtained from 293 cells, without generating detectable recombinant replication competent adenovirus (RCA).
Career Highlights
Ralston is associated with Schering Corporation, where he has contributed to various innovative projects. His expertise in biotechnology has positioned him as a valuable asset in the field.
Collaborations
Some of his notable coworkers include John A. Howe and Ken N. Wills, who have collaborated with him on various projects within the company.
Conclusion
Robert Orville Ralston, II's contributions to the field of biotechnology through his innovative patents and collaborations highlight his importance as an inventor. His work continues to influence advancements in gene therapy and vaccine production.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile