Location History:
- San Francisco, CA (US) (2012 - 2016)
- Redwood City, CA (US) (2016 - 2019)
Company Filing History:
4 out of 3,222 
3 out of 141 
1 out of 318 
Years Active: 2012-2019
Title: The Innovations of Robert L. Yauch
Introduction
Robert L. Yauch is a notable inventor based in Redwood City, CA (US). He has made significant contributions to the field of cancer research, particularly in understanding drug resistance mechanisms. With a total of 6 patents, his work has had a profound impact on therapeutic strategies for cancer treatment.
Latest Patents
One of Yauch's latest patents is titled "Mutant Smoothened and Methods of Using the Same." This patent addresses the emergence of mutations in tyrosine kinases following treatment of cancer patients with molecular-targeted therapy. It describes mutations in the serpentine receptor, Smoothened (SMO), which lead to resistance against Hedgehog (Hh) pathway inhibitors, such as in medulloblastoma. The patent highlights amino acid substitutions in conserved residues of SMO that maintain Hh signaling but prevent the binding of the Hh pathway inhibitor, GDC-0449, thus allowing the pathway to remain active. Additionally, the patent provides novel mutant SMO proteins and nucleic acids, along with screening methods to detect SMO mutations and identify drugs that can specifically modulate mutant SMO exhibiting drug resistance. Another significant patent is focused on "Methods of Treating and Preventing Cancer Drug Resistance," which outlines combination therapies for treating pathological conditions like cancer using an antagonist of FGFR signaling.
Career Highlights
Throughout his career, Robert L. Yauch has worked with prominent companies in the biotechnology sector, including Genentech, Inc. and Curis, Inc. His innovative research has contributed to advancements in cancer therapies and has positioned him as a key figure in the field.
Collaborations
Yauch has collaborated with esteemed colleagues such as Frederic J. De Sauvage and John D. Haley. These collaborations have further enriched his research and have led to significant advancements in understanding cancer treatment.
Conclusion
Robert L. Yauch's contributions to cancer research through his patents and collaborations have made a lasting impact on the field. His innovative approaches to addressing drug resistance continue to influence therapeutic strategies for cancer treatment.