The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2019
Filed:
Feb. 04, 2016
Genentech, Inc., South San Francisco, CA (US);
Curis, Inc., Lexington, MA (US);
Assistance Publique-hopitaux DE Paris, Paris, FR;
Universite Paris Diderot—paris 7, Paris, FR;
Frederic J. De Sauvage, Foster City, CA (US);
Robert L. Yauch, Redwood City, CA (US);
Gerrit J. P. Dijkgraaf, South San Francisco, CA (US);
Hayley Sharpe, San Francisco, CA (US);
Nicole Basset-Seguin, Paris, FR;
Genentech, Inc., South San Francisco, CA (US);
Curis, Inc., Lexington, MA (US);
Assistance Publique-Hopitaux de Paris, Paris, FR;
Universite Paris Diderot—Paris 7, Paris, FR;
Abstract
The emergence of mutations in tyrosine kinases following treatment of cancer patients with molecular-targeted therapy represents a major mechanism of acquired drug resistance. Here, mutations in the serpentine receptor, Smoothened (SMO) are described, which result in resistance to a Hedgehog (Hh) pathway inhibitor, such as in medulloblastoma. Amino acid substitutions in conserved residues of SMO maintain Hh signaling, but result in the inability of the Hh pathway inhibitor, GDC-0449, to bind SMO and suppress the pathway. In some embodiments, the disclosure provides for novel mutant SMO proteins and nucleic acids and for screening methods to detect SMO mutations and methods to screen for drugs that specifically modulate mutant SMO exhibiting drug resistance.