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Years Active: 2019
Title: Hayley Sharpe: Innovator in Cancer Research
Introduction
Hayley Sharpe is a prominent inventor based in San Francisco, CA. She has made significant contributions to the field of cancer research, particularly in understanding drug resistance mechanisms. Her innovative work has led to the development of a patent that addresses critical challenges in cancer treatment.
Latest Patents
Hayley Sharpe holds a patent titled "Mutant Smoothened and Methods of Using the Same." This patent focuses on the emergence of mutations in tyrosine kinases following treatment of cancer patients with molecular-targeted therapy. It describes mutations in the serpentine receptor, Smoothened (SMO), which result in resistance to Hedgehog (Hh) pathway inhibitors, such as in medulloblastoma. The patent outlines how amino acid substitutions in conserved residues of SMO maintain Hh signaling but prevent the binding of the Hh pathway inhibitor, GDC-0449, thereby allowing the pathway to remain active. The disclosure also provides novel mutant SMO proteins and nucleic acids, along with screening methods to detect SMO mutations and identify drugs that specifically target mutant SMO exhibiting drug resistance.
Career Highlights
Throughout her career, Hayley has worked with leading companies in the biotechnology sector, including Genentech, Inc. and Curis, Inc. Her experience in these organizations has allowed her to collaborate with some of the brightest minds in the industry, further enhancing her expertise in cancer research.
Collaborations
Hayley has collaborated with notable colleagues such as Frederic J De Sauvage and Robert L Yauch. These partnerships have contributed to her success and the advancement of her research in the field.
Conclusion
Hayley Sharpe is a trailblazer in cancer research, with a focus on understanding and overcoming drug resistance. Her innovative patent and collaborations with esteemed colleagues highlight her commitment to advancing medical science. Her work continues to inspire future innovations in the fight against cancer.