Company Filing History:
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Title: The Innovations of Robert L. Vogel: Pioneering Discoveries in Human Steroid Receptors
Introduction: Robert L. Vogel, an accomplished inventor based in Richboro, Pennsylvania, has made significant contributions to the field of biomedicine, particularly through his groundbreaking work on human steroid receptors. With three patents to his name, his innovative approach has furthered the understanding of hormonal regulation and gene expression.
Latest Patents: One of Vogel's latest patents is centered on the human steroid receptor, specifically a method for finding transcription activators of the NER (Nuclear Endocrine Receptor) steroid hormone. The NER receptor is a novel member of the steroid hormone receptor superfamily, developed through cDNA cloning from a human osteosarcoma SAOS-2/B10 cell library. This patent includes the complete sequence of human NER complementary DNA (Seq. ID No. 1) and outlines expression systems, including a COS stable expression system. Furthermore, it describes the expressed protein (SEQ. ID No. 2) and presents an assay using the COS expression system to identify agents that activate transcription mediated by the NER receptor. The agents identified through this method could enhance the activity of modulators of G-protein coupled receptors within the steroid hormone receptor superfamily.
Career Highlights: Throughout his career, Vogel has worked with notable organizations that have contributed to his research and innovations. He was affiliated with Merck & Company, Inc. and the Medical College of Pennsylvania, where he honed his expertise in pharmacology and molecular biology. His work in these institutions has helped bridge the gap between basic research and clinical applications.
Collaborations: Collaboration has been a cornerstone of Vogel's professional journey. He has had the opportunity to work alongside esteemed colleagues such as Gideon A. Rodan and Azriel Schmidt. These partnerships have enhanced his research capabilities and helped propel his innovative projects forward.
Conclusion: Robert L. Vogel is a distinguished inventor whose work continues to influence the biomedicine field positively. With valuable patents that unveil the complexities of human steroid receptors, Vogel’s contributions are integral to advancing medical science. His collaborations and career highlights underscore a commitment to innovation that inspires future research endeavors.